The efficacy of a local therapeutic agent in deseased tissue depends basically on its absorption. The percutaneous absorption ofthe active ingredient MPS has been proven in various studies with direct and indirect methods.

Stütgen et al. reported the results of a highly interesting pharmacological study in humans:

Punched samples of different specimens of human skin were treated with tritium labelled MPS and heparin. The skin samples were fixed into a perfusion chamber. Perfusion fluid and skin were analysed 180 and 360 min later.

The results not only confirmed the absorption of MPS but also showed that MPS reaches the individual dermal layers in therapeutically effective concentration. The penetration rates of MPS greatly exceeded those of heparin.